FIGURE

Fig. 6

ID

ZDB-FIG-081104-29

Publication

Laue et al., 2008 - Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development

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Fig. 6

cyp26b1 mutants and morphants display precocious and increased ossification of vertebral centra in the developing vertebral column. (A-K) Alizarin Red stainings of zebrafish larvae of genotype indicated in the upper right corners and at stages indicated in the lower right corners. (A-F,I-K) Lateral views; (G,H) transverse sections. Arrows in A indicate time course of centra ossification, starting at centra 3/4. In contrast to the segmented ossification of the wild-type larva (A,D,I,K), the cyp26b1 mutant (C,J) and morphant (F) show uniform and caudally extended perichordal ossification. See text for details. bop, basioccipital articulatory process.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cyp26b1^{ti230g/ti230g} WT + MO5-cyp26b1 cyp26b1^ti230g/+
Knockdown Reagent:	MO5-cyp26b1
Observed In:	centrum regulation of ossification
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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