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Fig. 9

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ZDB-FIG-071001-49

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Semina et al., 2006 - Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish

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Fig. 9

Histological comparison of adult wild-type mosaic, lens-ablated, and bal^a69 mosaic eyes. (A–D) Iridocorneal angle analysis in (A) wild-type mosaics showed normal morphology including annular ligament and ciliary canal. In (B) lens-ablated fish, cell differentiation in the angle appeared normal, although the ciliary canal was often narrow. Angle differentiation in (C, D) bal^a69 mutant mosaics was often abnormal including defects in the annular ligament (arrows), iris, and ciliary margin. In the posterior region, the iridophore layer (arrowheads) appeared normal in (E) wild-type mosaics and (F) lens-ablated fish but was often thick in (G) bal^a69 mutant mosaics. Whereas the retinal ganglion cell (RGC) layer was dysmorphic in both lens-ablated and bal^a69 mutant mosaics with lens degeneration, focal dysplasias within the RGC layer were also observed in (I) bal^a69 mutant mosaics with normal lenses. No dysplasias or other phenotypes were noted in (H) wild-type mosaics.

Expression Data

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Acknowledgments

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Reprinted from Developmental Biology, 299(1), Semina, E.V., Bosenko, D.V., Zinkevich, N.C., Soules, K.A., Hyde, D.R., Vihtelic, T.S., Willer, G.B., Gregg, R.G., and Link, B.A., Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish, 63-77, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.