FIGURE

Fig. 3

ID

ZDB-FIG-061106-4

Publication

Semina et al., 2006 - Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish

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Fig. 3

Laminin alpha 1 expression during eye development. In situ hybridization for lama1 transcripts (purple) was investigated at (A) 24 hpf, (B) 48 hpf, and (C) 72 hpf. Laminin-1 immunoreactivity (red) was examined at (D) 24 hpf, (E) 48 hpf, and (F) 72 hpf and found to be associated with the cornea, sclera, lens capsule, outer segments of photoreceptors, and optic nerve (arrows in panel E). By 72 hpf, immunoreactivity was also observed in the developing anterior segment angle (arrowheads in panel F).

Expression Data

Gene:	lama1
Fish:	WT
Anatomical Terms:	cornea immature eye lens retina
Stage Range:	Prim-5 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 299(1), Semina, E.V., Bosenko, D.V., Zinkevich, N.C., Soules, K.A., Hyde, D.R., Vihtelic, T.S., Willer, G.B., Gregg, R.G., and Link, B.A., Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish, 63-77, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.