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Fig. 8

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ZDB-FIG-071001-48

Publication

Semina et al., 2006 - Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish

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Fig. 8

Ocular genetic mosaics of bal^a69 mutant and wild-type cells. (A) 24 hpf genetic mosaic embryos showing a high contribution of lineage-labeled donor cells (red) to ocular structures. (B) 5 dpf whole embryo phenotypes of wild-type donor to wild-type host (top) and bal^a69-donor to wild-type host ocular chimeras (bottom). Note the irregular pupil in the absence of other body phenotypes in the bal^a69 to wild-type ocular mosaic. (C) Ocular phenotype of wild-type to wild-type mosaics (top) show no abnormalities, whereas (D, E) bal^a69 to wild-type ocular mosaics show a spectrum of phenotypes including (D) pinhole pupils and severe microphthalmia and (E) iridophore patterning defects with cataracts.

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Acknowledgments

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Reprinted from Developmental Biology, 299(1), Semina, E.V., Bosenko, D.V., Zinkevich, N.C., Soules, K.A., Hyde, D.R., Vihtelic, T.S., Willer, G.B., Gregg, R.G., and Link, B.A., Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish, 63-77, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.