FIGURE

Fig. 1

ID

ZDB-FIG-070813-17

Publication

Wendl et al., 2007 - Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals

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Fig. 1

Thyroid development is impaired in hands off mutant zebrafish embryos. Anterior is to the left. Stages are indicated bottom left, genotype top right and staining/marker bottom right. Arrows show thyroid primordium; arrowheads show pharyngeal endoderm. Ventral (A,B,Q), dorsal (C,D) and lateral (E-P) views are shown. T4 (thyroid hormone) immunostaining (A,B,Q) and in situ hybridisation (C-P). (A,B) In han^s6 embryos, no T4-producing follicles are detectable. (C,D) Pharyngeal endoderm appears to be normal in han^s6 mutants. (E-K) Expression of thyroid developmental markers. (L-N) The thyroid differentiation marker slc5a5 is expressed in approximately 10% of han^s6 mutant embryos. (O-Q) In han^c99 mutants, both primordium and differentiated thyroid are reduced. hy, hypothalamus; mhb midbrain-hindbrain boundary.

Expression Data

Genes:	foxa2 hhex nkx2.4b pax2a slc5a5
Fish:	WT Df(Chr01:hand2)s6/s6 hand2^c99/c99
Anatomical Terms:	hypothalamus midbrain hindbrain boundary pharyngeal endoderm thyroid follicle thyroid primordium
Stage Range:	Prim-5 to Pec-fin

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	Df(Chr01:hand2)s6/s6 hand2^c99/c99
Observed In:	pharyngeal endoderm thyroid follicle thyroid gland development thyroid primordium
Stage Range:	Prim-5 to Days 7-13

Phenotype Detail

Acknowledgments

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