FIGURE

Fig. 5

ID

ZDB-FIG-070813-21

Publication

Wendl et al., 2007 - Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals

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Fig. 5

Elimination of han expression sites in the pharyngeal area does not influence thyroid development. Labelling is as in Fig. 1. (A-D) In edn1 morphants (B), han (hand2) expression in the first (1) and third branchial arches is eliminated. In tfap2a(low, lockjaw) morphants (C), hand2 expression in the second branchial arch (2) is missing. In double morphants (D), hand2-expressing cells are only present in arch-associated cells (arrowheads), as well as some weak expression in the endoderm (confirmed on sections, data not shown). (E) The thyroid (arrow) appears normal in edn1/tfap2a double morphants. (F) In foxi1 morphants, hand2 expression in arch-associated cells (arrowhead) is specifically ablated. (G) Normal expression of nk2.1a in foxi1 morphants (arrow). h, heart.

Expression Data

Genes:	hand2 nkx2.4b slc5a5
Fish:	WT WT + MO1-edn1 WT + MO1-foxi1 WT + MO2-tfap2a WT + MO1-edn1 + MO2-tfap2a
Knockdown Reagents:	MO1-edn1 MO1-foxi1 MO2-tfap2a
Anatomical Terms:	endoderm heart tube pharyngeal arch thyroid follicle
Stage Range:	Prim-5 to Pec-fin

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-foxi1 WT + MO1-edn1 + MO2-tfap2a
Knockdown Reagents:	MO1-edn1 MO1-foxi1 MO2-tfap2a
Observed In:	thyroid follicle
Stage Range:	Long-pec to Pec-fin

Phenotype Detail

Acknowledgments

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