FIGURE

Fig. 6

ID

ZDB-FIG-070813-22

Publication

Wendl et al., 2007 - Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

FGF signalling is required for thyroid development. Labelling is as in Fig. 1. Anterior is to the left. Lateral (A-F,I-L) and ventral (G,H) views are shown. (A-F) Expression of thyroid markers in ace mutants and in wild-type (wt) siblings. (G,H) ace larvae have a strong reduction in thyroid gland size. (I,K) In DMSO-treated control embryos, the thyroid appears normal. (J,L,M) Following different stages of su5402 treatment, the thyroid is completely lost. (J,L) Example embryos without thyroid; (M) the complete data set. Blue bars, embryos with thyroidal nk2.1a expression; red bars, slc5a5 expression. Arrows point to the thyroid primordium; the asterisk indicates the absent midbrain-hindbrain boundary (MHB) in ace mutants.hy, hypothalamus; mhb, midbrain-hindbrain boundary, ss somite stage.

Expression Data

Genes:	hhex nkx2.4b pax2a slc5a5
Fish:	WT fgf8a^{ti282a/ti282a}
Condition:	chemical treatment: SU5402
Anatomical Terms:	hypothalamus midbrain hindbrain boundary pharyngeal endoderm thyroid follicle thyroid primordium
Stage Range:	Prim-5 to Pec-fin

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fgf8a^{ti282a/ti282a}
Observed In:	thyroid primordium
Stage Range:	Prim-5 to Prim-15

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development