Gene
slc5a5
- ID
- ZDB-GENE-060503-585
- Name
- solute carrier family 5 member 5
- Symbol
- slc5a5 Nomenclature History
- Previous Names
-
- NIS (1)
- si:ch211-200a16.4
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables sodium:iodide symporter activity. Predicted to be involved in iodide transmembrane transport and sodium ion transport. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane. Is expressed in brain; ovary; pharynx; thyroid follicle; and thyroid primordium. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thyroid dyshormonogenesis 1 | Alliance | Thyroid dyshormonogenesis 1 | 274400 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sodium/glucose symporter superfamily | Sodium/solute symporter | Sodium:Solute Symporter (SSF) |
|---|---|---|---|---|
|
UniProtKB:A0A8M9Q9Q5
|
438 | |||
|
UniProtKB:A4IG60
|
601 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc5a5-201
(1)
|
Ensembl | 1,698 nt | ||
| mRNA |
slc5a5-202
(1)
|
Ensembl | 2,029 nt |
Interactions and Pathways
No data available
Plasmids
No data available