Gene
foxa2
- ID
- ZDB-GENE-980526-404
- Name
- forkhead box A2
- Symbol
- foxa2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in axial mesoderm morphogenesis; endoderm development; and nervous system development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in several structures, including central nervous system; digestive system; endoderm; mesoderm; and swim bladder. Orthologous to human FOXA2 (forkhead box A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 153 figures from 121 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR013638 | Fork-head N-terminal |
| Domain | IPR018533 | Forkhead box protein, C-terminal |
| Family | IPR050211 | Forkhead box domain-containing protein |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Forkhead box domain-containing protein | Forkhead box protein, C-terminal | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Fork-head N-terminal | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q07342
|
409 |
Interactions and Pathways
No data available
Plasmids
No data available