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Fig. 7

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ZDB-FIG-061219-7

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Mendelsohn et al., 2006 - Atp7a determines a hierarchy of copper metabolism essential for notochord development

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Fig. 7

Interaction of atp7a dosage and developmental copper deficiency

A and B) Wild-type embryos appear normal in 100 nM neocuproine (A); cal heterozygotes display loss of all melanin pigment at this same dose (B).

C) The pleiotropic phenotype of copper deficiency is observed in all cal homozygotes in 100 nM neocuproine.

D–K) Embryos injected with control MO (D–G) display a phenotypic dose-response curve in neocuproine of the notochord (arrowheads) and melanin pigment (arrows) that is altered in embryos injected with atp7a-targeted MO (H–K). All embryos were treated continuously from 3 hpf with the indicated dose of drug.

Expression Data

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Antibody Labeling

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Acknowledgments

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Reprinted from Cell Metabolism, 4(2), Mendelsohn, B.A., Yin, C., Johnson, S.L., Wilm, T.P., Solnica-Krezel, L., and Gitlin, J.D., Atp7a determines a hierarchy of copper metabolism essential for notochord development, 155-162, Copyright (2006) with permission from Elsevier. Full text @ Cell Metab.