FIGURE

Fig. 4

ID

ZDB-FIG-061206-9

Publication

Lee et al., 2006 - Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis

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Fig. 4

Lef1 is required for proneural and neuronal gene expression in the posterior hypothalamus. White circles outline posterior hypothalamus in whole-mount views, and black ovals outline posterior hypothalamus in cross-sections. Lines in whole-mount images show plane of corresponding cross-sections. (A-D) Expression of sox3 is absent in the posterior hypothalamus of lef1 morphants at 24 hpf. (E-H) Expression of zash1a is absent in the posterior hypothalamus of lef1 morphants at 28 hpf. (I-P) Expression of dlx2 and isl1 are absent in the posterior hypothalamus of lef1 morphants at 30 hpf. (Q-T) Expression of ngn1 and olig2, which are expressed in the posterior tuberculum, is unaffected in the posterior tuberculum of lef1 morphants.

Expression Data

Genes:	ascl1a dlx2a isl1a lef1 neurog1 olig2 sox3
Fish:	WT WT + MO2-lef1
Knockdown Reagent:	MO2-lef1
Anatomical Terms:	caudal tuberculum forebrain hypothalamus
Stage Range:	Prim-5 to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-lef1
Knockdown Reagent:	MO2-lef1
Observed In:	forebrain neuron development hypothalamus neuron
Stage Range:	Prim-5 to Prim-15

Phenotype Detail

Acknowledgments

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