FIGURE

Fig. 4

ID

ZDB-FIG-060912-10

Publication

Kazakova et al., 2006 - A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes

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Fig. 4

CNS phenotype of ott mutants. Transverse sections through the spinal cord of 80 hpf larvae. (A–F) Myelin protein expression in wild type (A, C, E) and ott (B, D, F) mutant fish. (A, B) mbp is not expressed in ott mutants. (C, D) Plp1b is not expressed in ott mutants. (E, F) Mpz is weakly present in some grey matter cells in ott mutants. (G, H) In wild type fish, olig2-expressing cells have migrated to the periphery by 80 hpf (G) whereas olig2 expression is still restricted to the ventral ventricular zone in ott mutants (H). (I, J) The distribution of cells expressing the motor neuron marker isl1 is similar in wild type (I) and ott mutant (J) fish. (K, L) Electronmicrographs of spinal cord axons ensheathed by loosely wrapped immature myelin in wild type (K) and ott mutant (L) fish. Scale bars in panels K and L, 200 nm.

Expression Data

Genes:	isl1a mbpa mpz olig2 plp1b
Fish:	WT med12^ta76b/ta76b
Anatomical Terms:	spinal cord spinal cord motor neuron
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	med12^ta76b/ta76b
Observed In:	myelinating Schwann cell spinal cord motor neuron
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 297(1), Kazakova, N., Li, H., Mora, A., Jessen, K.R., Mirsky, R., Richardson, W.D., and Smith, H.K., A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes, 1-13, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.