Gene
mpz
- ID
- ZDB-GENE-010724-4
- Name
- myelin protein zero
- Symbol
- mpz Nomenclature History
- Previous Names
-
- p0
- sc:d0186
- wu:fc04b11
- wu:fi30g06
- zgc:103775
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Localizes to myelin sheath. Human ortholog(s) of this gene implicated in neuromuscular disease (multiple). Is expressed in several structures, including Rohon-Beard neurons; basal plate midbrain region; central nervous system; cranial nerve; and oligodendrocyte. Orthologous to human MPZ (myelin protein zero).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 43 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103775 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Charcot-Marie-Tooth disease dominant intermediate D | Alliance | Charcot-Marie-Tooth disease, dominant intermediate D | 607791 |
Charcot-Marie-Tooth disease type 1B | Alliance | Charcot-Marie-Tooth disease, type 1B | 118200 |
Charcot-Marie-Tooth disease type 2I | Alliance | Charcot-Marie-Tooth disease, type 2I | 607677 |
Charcot-Marie-Tooth disease type 2J | Alliance | Charcot-Marie-Tooth disease, type 2J | 607736 |
Charcot-Marie-Tooth disease type 3 | Alliance | Dejerine-Sottas disease | 145900 |
Hypomyelinating neuropathy, congenital, 2 | 618184 | ||
Roussy-Levy syndrome | 180800 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR003599 | Immunoglobulin domain subtype |
Domain | IPR007110 | Immunoglobulin-like domain |
Domain | IPR013106 | Immunoglobulin V-set domain |
Domain | IPR047014 | Myelin P0 protein, Ig-like domain |
Family | IPR000920 | Myelin P0 protein-related |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
Protein | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin V-set domain | Myelin P0 protein, Ig-like domain | Myelin P0 protein-related |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A2R8QN30
|
228 | |||||||
UniProtKB:Q8JFG6
|
203 | |||||||
UniProtKB:A0A0R4IS04
|
212 | |||||||
UniProtKB:A0A8M6Z0S2
|
206 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
mpz-201
(1)
|
Ensembl | 606 nt | ||
mRNA |
mpz-202
(1)
|
Ensembl | 2,344 nt | ||
mRNA |
mpz-203
(1)
|
Ensembl | 1,389 nt | ||
mRNA |
mpz-204
(1)
|
Ensembl | 943 nt | ||
mRNA |
mpz-206
(1)
|
Ensembl | 639 nt | ||
mRNA |
mpz-207
(1)
|
Ensembl | 606 nt | ||
mRNA |
mpz-208
(1)
|
Ensembl | 1,445 nt | ||
ncRNA |
mpz-002
(1)
|
Ensembl | 598 nt |
Interactions and Pathways
No data available
Plasmids
No data available