Gene

mpz

ID

ZDB-GENE-010724-4

Name

myelin protein zero

Symbol

mpz Nomenclature History

Previous Names

p0
sc:d0186
wu:fc04b11
wu:fi30g06
zgc:103775

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Localizes to myelin sheath. Human ortholog(s) of this gene implicated in neuromuscular disease (multiple). Is expressed in several structures, including Rohon-Beard neurons; basal plate midbrain region; central nervous system; cranial nerve; and oligodendrocyte. Orthologous to human MPZ (myelin protein zero).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

43 figures from 22 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:103775 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mpz Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease dominant intermediate D	Alliance	Charcot-Marie-Tooth disease, dominant intermediate D	607791
Charcot-Marie-Tooth disease type 1B	Alliance	Charcot-Marie-Tooth disease, type 1B	118200
Charcot-Marie-Tooth disease type 2I	Alliance	Charcot-Marie-Tooth disease, type 2I	607677
Charcot-Marie-Tooth disease type 2J	Alliance	Charcot-Marie-Tooth disease, type 2J	607736
Charcot-Marie-Tooth disease type 3	Alliance	Dejerine-Sottas disease	145900
		Hypomyelinating neuropathy, congenital, 2	618184
		Roussy-Levy syndrome	180800

Associated With mpz Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013106	Immunoglobulin V-set domain
Domain	IPR047014	Myelin P0 protein, Ig-like domain
Family	IPR000920	Myelin P0 protein-related
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Immunoglobulin domain subtype	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin V-set domain	Myelin P0 protein, Ig-like domain	Myelin P0 protein-related
UniProtKB:A0A2R8QN30 InterPro	228
UniProtKB:Q8JFG6 InterPro	203
UniProtKB:A0A0R4IS04 InterPro	212
UniProtKB:A0A8M6Z0S2 InterPro	206

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mpz-201 (1) Ensembl	Ensembl	606 nt	Select Tool ZFIN BLAST
mRNA	mpz-202 (1) Ensembl	Ensembl	2,344 nt	Select Tool ZFIN BLAST
mRNA	mpz-203 (1) Ensembl	Ensembl	1,389 nt	Select Tool ZFIN BLAST
mRNA	mpz-204 (1) Ensembl	Ensembl	943 nt	Select Tool ZFIN BLAST
mRNA	mpz-206 (1) Ensembl	Ensembl	639 nt	Select Tool ZFIN BLAST
mRNA	mpz-207 (1) Ensembl	Ensembl	606 nt	Select Tool ZFIN BLAST
mRNA	mpz-208 (1) Ensembl	Ensembl	1,445 nt	Select Tool ZFIN BLAST
ncRNA	mpz-002 (1) Ensembl	Ensembl	598 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-mpz		mpz		Rabbit	IHC WB		2
Ab2-mpz		mpz		Rabbit	IHC WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations