Gene
plp1b
- ID
- ZDB-GENE-030710-6
- Name
- proteolipid protein 1b
- Symbol
- plp1b Nomenclature History
- Previous Names
-
- dm20 (1)
- DMalpha2a
- DMalpha2b
- DMalpha2c
- fv76c02
- wu:fv76c02
- zgc:91786
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to be involved in neuron projection development. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Is expressed in nervous system. Orthologous to human PLP1 (proteolipid protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 33 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu446 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 2 | Alliance | Spastic paraplegia 2, X-linked | 312920 |
| Pelizaeus-Merzbacher disease | Alliance | Pelizaeus-Merzbacher disease | 312080 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001614 | Myelin proteolipid protein PLP |
Domain Details Per Protein
| Protein | Length | Myelin proteolipid protein PLP |
|---|---|---|
|
UniProtKB:A0A8M2BCB3
|
280 | |
|
UniProtKB:Q8UUT2
|
257 | |
|
UniProtKB:Q8UUT5
|
245 | |
|
UniProtKB:Q8UUT3
|
279 |
Interactions and Pathways
No data available
Plasmids
No data available