Gene

mbpa

ID

ZDB-GENE-030128-2

Name

myelin basic protein a

Symbol

mbpa Nomenclature History

Previous Names

mbp
cb274 (1)
fj33b11
wu:fj33b11
wu:fq15b02
zgc:136630

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to be a structural constituent of myelin sheath. Localizes to myelin sheath and plasma membrane. Human ortholog(s) of this gene implicated in multiple sclerosis. Is expressed in several structures, including EVL; male organism; nervous system; otic vesicle; and periderm. Orthologous to human MBP (myelin basic protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

193 figures from 112 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb274 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mbpa Human Ortholog

No data available

Associated With mbpa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR000548	Myelin basic protein

Domain Details Per Protein

Protein	Length	Myelin basic protein
UniProtKB:F8W3W8 InterPro	95
UniProtKB:I3ITP3 InterPro	137
UniProtKB:A0A8M9P2C7 InterPro	130
UniProtKB:F8W2M5 InterPro	91
UniProtKB:Q5I2C7 InterPro	88
UniProtKB:F8W3A0 InterPro	79
UniProtKB:E7F0U0 InterPro	100
UniProtKB:F8W3M5 InterPro	125
UniProtKB:F8W3V8 InterPro	107

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mbpa-201 (1) Ensembl	Ensembl	1,719 nt	Select Tool
mRNA	mbpa-202 (1) Ensembl	Ensembl	1,610 nt	Select Tool
mRNA	mbpa-203 (1) Ensembl	Ensembl	761 nt	Select Tool
mRNA	mbpa-205 (1) Ensembl	Ensembl	581 nt	Select Tool
mRNA	mbpa-206 (1) Ensembl	Ensembl	861 nt	Select Tool
mRNA	mbpa-207 (1) Ensembl	Ensembl	497 nt	Select Tool
mRNA	mbpa-208 (1) Ensembl	Ensembl	737 nt	Select Tool
mRNA	mbpa-209 (1) Ensembl	Ensembl	761 nt	Select Tool
mRNA	mbpa-210 (1) Ensembl	Ensembl	560 nt	Select Tool
mRNA	mbpa-211 (1) Ensembl	Ensembl	869 nt	Select Tool
ncRNA	mbpa-006 (1) Ensembl	Ensembl	1,043 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-mbp	polyclonal	mbpa		Rabbit	IHC		41

Plasmids

Addgene:pZL1-ZF - myelin basic protein a (mbpa)

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations