FIGURE

Fig. 2

ID

ZDB-FIG-060130-1897

Publication

Ramel et al., 2005 - WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation

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Fig. 2

Wnt8 and BMP2b are necessary to repress anterior and posterior axial mesoderm and to maintain non-axial mesoderm. In situ hybridization for gsc (anterior axial mesoderm, A–E), myoD (adaxial mesoderm, F–J), and flh (posterior axial mesoderm, K–O) at bud stage. Genotypes are indicated above each column. Main panels A–E: lateral views, dorsal right. Insets: dorsal view, anterior up. F–O: dorsal views, anterior up. Insets: posterior view, dorsal up. Note that the slightly widened adaxial domain in swr mutants (G) and the progressive widening of the axial domain as wnt8 MO embryos have a reduced dosage of bmp2b (C–E, H–J, M–O).

Expression Data

Genes:	gsc myod1 noto
Fish:	AB bmp2b^{tc300a/tc300a} (TU) AB + MO3-wnt8a + MO4-wnt8a + MO5-wnt8a + MO6-wnt8a bmp2b^{tc300a/tc300a} + MO3-wnt8a + MO4-wnt8a + MO5-wnt8a + MO6-wnt8a (TU)
Knockdown Reagents:	MO3-wnt8a MO4-wnt8a MO5-wnt8a MO6-wnt8a
Anatomical Terms:	axial mesoderm mesoderm unspecified
Stage:	Bud

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 287(2), Ramel, M.C., Buckles, G.R., Baker, K.D., and Lekven, A.C., WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation, 237-248, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.