FIGURE

Fig. 1

ID

ZDB-FIG-070917-98

Publication

Ramel et al., 2005 - WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

Wnt8 and BMP2b are required to maintain axial/non-axial polarity. Morphology of bud stage embryos. Genotypes are indicated above each column. A–D: dorsal views. F–I: lateral views, dorsal right. Arrows in panels A–C indicate the width of the notochord when visible. Double arrows in panels F–I indicate the length of the A/P axis, asterisks indicate rostral edge of anterior axial mesoderm. Note the shortened axis of wnt8 MO embryos (C, H) and the posterior displacement of the axis in wnt8 MO; swr/+ embryos (D, I). wnt8 MO; swr/swr embryos display a large mass of cells at the animal pole (arrows in E and J) and do not have a recognizable D/V polarity.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bmp2b^{tc300a/tc300a} (TU) AB + MO3-wnt8a + MO4-wnt8a + MO5-wnt8a + MO6-wnt8a bmp2b^tc300a/+ + MO3-wnt8a + MO4-wnt8a + MO5-wnt8a + MO6-wnt8a (TU) bmp2b^{tc300a/tc300a} + MO3-wnt8a + MO4-wnt8a + MO5-wnt8a + MO6-wnt8a (TU)
Knockdown Reagents:	MO3-wnt8a MO4-wnt8a MO5-wnt8a MO6-wnt8a
Observed In:	axis convergent extension involved in gastrulation dorsal/ventral pattern formation mesoderm formation notochord notochord development polarity specification of dorsal/ventral axis post-vent region mesoderm trunk mesoderm whole organism
Stage:	Bud

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 287(2), Ramel, M.C., Buckles, G.R., Baker, K.D., and Lekven, A.C., WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation, 237-248, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.