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Phenotype Figure Summary
Marker:
sec13
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Niu
et al.
, 2014
Fig. 1
sec13
sq198/sq198
eye decreased size, abnormal
retina apoptotic process increased process quality, abnormal
retina disorganized, abnormal
retina has fewer parts of type retinal ganglion cell, abnormal
retina layer formation process quality, abnormal
retinal pigmented epithelium distended, abnormal
Fig. 11
sec13
sq198/sq198
retina apoptotic process increased process quality, abnormal
Fig. 12
sec13
sq198/sq198
retina apoptotic process increased process quality, abnormal
retinal outer nuclear layer disorganized, abnormal
Fig. 2
WT + MO1-sec13
, 
sec13
sq198/sq198
eye decreased size, abnormal
Fig. 3
sec13
sq198/sq198
retinal ganglion cell endoplasmic reticulum morphology, abnormal
retinal inner nuclear layer endoplasmic reticulum morphology, abnormal
retinal outer nuclear layer endoplasmic reticulum morphology, abnormal
Fig. 6
sec13
sq198/sq198
retina layer formation process quality, abnormal
retinal outer nuclear layer disorganized, abnormal
Fig. 7
sec13
sq198/sq198
retina nuclear pore malformed, abnormal
retinal ganglion cell nuclear pore malformed, abnormal
retinal inner nuclear layer nuclear pore malformed, abnormal
retinal outer nuclear layer nuclear pore malformed, abnormal
Fig. 8
sec13
sq198/sq198
retina layer formation process quality, abnormal
retina poly(A)+ mRNA export from nucleus decreased process quality, abnormal
Fig. 9
sec13
sq198/sq198
intestine nuclear pore malformed, abnormal
intestine poly(A)+ mRNA export from nucleus decreased process quality, abnormal
liver nuclear pore malformed, abnormal
liver poly(A)+ mRNA export from nucleus decreased process quality, abnormal
pancreas decreased size, abnormal
pancreas poly(A)+ mRNA export from nucleus decreased process quality, abnormal
Schmidt
et al.
, 2013
Fig. 1
WT + MO2-sec13
eye decreased size, abnormal
head decreased size, abnormal
photoreceptor cell differentiation disrupted, abnormal
photoreceptor outer segment layer absent, abnormal
retina decreased size, abnormal
retina layer formation disrupted, abnormal
retina nucleus condensed, abnormal
retinal photoreceptor layer absent, abnormal
retinal pigmented epithelium hypertrophic, abnormal
Fig. 2
WT + MO2-sec13 + MO4-tp53
, 
WT + MO2-sec13
cell population proliferation decreased rate, abnormal
eye cell apoptotic, abnormal
fin kinked, abnormal
retina layer formation disrupted, abnormal
Fig. 3
WT + MO2-sec13
amacrine cell decreased amount, abnormal
Muller cell decreased amount, abnormal
Muller cell disoriented, abnormal
retina disorganized, abnormal
retina layer formation disrupted, abnormal
retinal cone cell decreased amount, abnormal
retinal ganglion cell decreased amount, abnormal
retinal rod cell aplastic, abnormal
Fig. 4
WT + MO2-sec13
eye photoreceptor cell endoplasmic reticulum dilated, abnormal
opsin transport disrupted, abnormal
photoreceptor cell differentiation disrupted, abnormal
photoreceptor cell morphology, abnormal
Fig. 5
WT + MO2-sec13
Bruch's membrane aplastic, abnormal
retina layer formation disrupted, abnormal
retinal photoreceptor layer absent, abnormal
retinal pigmented epithelium basement membrane aplastic, abnormal
retinal pigmented epithelium hypertrophic, abnormal
retinal pigmented epithelium neuroepithelial cell disorganized, abnormal
Niu
et al.
, 2012
Fig. 1
sec13
sq198/sq198
(AB)
exocrine pancreas decreased size, abnormal
intestine decreased size, abnormal
liver decreased size, abnormal
pharyngeal arch 3-7 malformed, abnormal
pronephric duct decreased thickness, abnormal
Fig. 10
sec13
sq198/sq198
(AB)
endoplasmic reticulum unfolded protein response increased occurrence, abnormal
Fig. 2
sec13
sq198/sq198
(AB)
apoptotic process increased occurrence, abnormal
cell cycle process arrested, abnormal
Fig. 3
sec13
sq198/sq198
(AB)
intestinal epithelium cell junction loose, abnormal
liver basement membrane aplastic, abnormal
Fig. 4
sec13
sq198/sq198
(AB)
chondrocyte deformed, abnormal
chondrocyte disorganized, abnormal
chondrocyte extracellular matrix decreased mass density, abnormal
chondrocyte vacuole increased accumulation chondrocyte cytoplasm, abnormal
extracellular matrix constituent secretion disrupted, abnormal
Fig. 5
sec13
sq198/sq198
(AB)
chondrocyte endoplasmic reticulum morphology, abnormal
hepatocyte endoplasmic reticulum morphology, abnormal
hepatocyte endoplasmic reticulum vacuolated, abnormal
intestinal epithelium endoplasmic reticulum dilated, abnormal
intestinal epithelium endoplasmic reticulum distended, abnormal
Fig. 6
AB + MO3-sec13
liver decreased size, abnormal
Fig. S1
sec13
sq198/sq198
(AB)
intestine decreased thickness, abnormal
liver decreased size, abnormal
swim bladder uninflated, abnormal
Fig. S11
sec13
sq198/sq198
(AB)
liver decreased size, abnormal
Fig. S2
sec13
sq198/sq198
(AB)
liver decreased size, abnormal
Fig. S3
sec13
sq198/sq198
(AB)
cell cycle process arrested, abnormal
Fig. S4
sec13
sq198/sq198
(AB)
intestinal villus decreased amount, abnormal
intestinal villus decreased length, abnormal
intestinal villus disorganized, abnormal
Townley
et al.
, 2008
Fig. 7
WT + MO2-sec13
, 
WT + MO1-sec13
cartilage development disrupted, abnormal
embryonic cranial skeleton morphogenesis disrupted, abnormal
eye decreased size, abnormal
eye malformed, abnormal
head decreased size, abnormal
Meckel's cartilage malformed, abnormal
neurocranium malformed, abnormal
pectoral fin kinked, abnormal
pectoral fin malformed, abnormal
Fig. S3
WT + MO2-sec13
, 
WT + MO1-sec13
cartilage development disrupted, abnormal
embryonic cranial skeleton morphogenesis disrupted, abnormal
eye decreased size, abnormal
head decreased size, abnormal
Meckel's cartilage malformed, abnormal
neurocranium malformed, abnormal
pectoral fin kinked, abnormal
pectoral fin malformed, abnormal
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