FIGURE

Fig. S11

ID

ZDB-FIG-120727-30

Publication

Niu et al., 2012 - Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish

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Fig. S11

Both Sec13 and Sec31a are dispensable for the islet development. (A-D) WISH using the liver specific marker fabp10a and endocrine pancreas specific marker insulin as probes showed that all sec13^sq198 mutant embryos and Sec31a-ATGMO morphants developed an islet that is not obvious different from that in the wild type control at 4 dpf. However, compared to the wild-type control (WT) (A), all sec13^sq198 mutant embryos (mu) (61/61) (B) and Sec31a-ATGMO morphants (33/87) examined (C) developed a small liver while majority of Sec31a-ATGMO morphants (54/87) appeared to be liverless (D). lv: liver; is: islet.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sec13^sq198/sq198 (AB) AB + MO1-sec31a
Knockdown Reagent:	MO1-sec31a
Observed In:	endocrine pancreas endocrine pancreas development liver
Stage:	Day 4

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 367(2), Niu, X., Gao, C., Jan Lo, L., Luo, Y., Meng, C., Hong, J., Hong, W., and Peng, J., Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish, 197-207, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.