FIGURE

Fig. 10

ID

ZDB-FIG-241219-38

Publication

Zadmajid et al., 2024 - Testosterone acts through membrane protein GPRC6A to cause cardiac edema in zebrafish embryos

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Fig. 10

A model for the GPRC6A-mediated signaling causing a cardiac phenotype. (A) Testosterone activation of GPRC6A leads to activation of second messenger pathways that cause cardiac defects. The GPCR kinase GRK3 can reduce GPRC6A activity by promoting recruitment of ?-arrestins. (B) Testosterone-mediated activation of GPRC6A inhibits or downregulates PAK1. (C) In the absence of testosterone, GPRC6A is less active. Created in BioRender. Gorelick, D. (2024) https://BioRender.com/y70f832.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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