FIGURE

Fig. 4

ID

ZDB-FIG-241126-13

Publication

Yu et al., 2024 - Aspirin reduces Ponatinib-induced cardiovascular toxic phenotypes and death in zebrafish

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Fig. 4

The effects of Ponatinib on transcriptome in zebrafish larvae. (A) 1 dpf zebrafish larvae were treated with 0.1 % DMSO or 3 ?M Ponatinib for 3 days. RNA sequencing was performed to identify the changes in gene expression. A volcano plot representing the expression level for each gene. Block dots represent no significant DEGs between control and Ponatinib groups. Red and blue dots represent up- and down-regulated genes, respectively. (B) The enriched gene sets based on GO pathways. (C) The enriched gene sets based on KEGG pathways. (D) Heat map representing 43 gene expression changes related to COX and MAPK signaling pathway. (E) 1 dpf zebrafish larvae were treated with 0.1 % DMSO or indicated concentrations of Ponatinib for 3 days. The mRNA levels of all L-type calcium channels-related genes in 4 dpf zebrafish were determined by RT-qPCR. Data are represented as mean � SEM. *P < 0.05 and ***P < 0.005 vs. control group.

Expression Data

Genes:	cacna1c cacna2d2a cacna2d2b cacnb3b
Fish:	AB
Condition:	chemical treatment by environment: ponatinib
Anatomical Term:	whole organism
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	chemical treatment by environment: ponatinib
Observed In:	whole organism
Stage:	Day 4

Phenotype Detail

Acknowledgments

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