FIGURE

Figure 7

ID

ZDB-FIG-240607-126

Publication

Fabian et al., 2024 - Comprehensive phenotypic characterization of an allelic series of zebrafish models of NEB-related nemaline myopathy

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Figure 7

Force production is reduced in neb mutants. (A–F) Plots of force production at optimal length (mean ± SEM). Across all frequency range of stimulation (1–200 Hz), all of the mutants showed lower force production than the wt controls at optimal sarcomere length. The reduction in force production is significant in both nonsense mutants and the splice mutants neb^hu28 and neb³⁴. Asterisks indicate p-values (* ≤ 0.05; ** ≤ 0.01; *** ≤ 0.001; **** ≤ 0.0001). See Supplemental Table 4 for measurements and statistics.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	neb^{hu2849/hu2849} neb^{sa11973/sa11973} neb^{sa15371/sa15371} neb^{sa21475/sa21475} neb^{sa30646/sa30646} neb^{sa34628/sa34628}
Observed In:	skeletal muscle skeletal muscle contraction
Stage:	Day 4

Phenotype Detail

Acknowledgments

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