FIGURE

FIGURE 5

ID

ZDB-FIG-240503-16

Publication

Zeng et al., 2024 - Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway

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FIGURE 5

Loss of cobll1a leads to abnormal RA metabolism in zebrafish. (A) Line chart of GSEA results with the right ordinate representing the enrichment score. (B) Cluster heat maps of RA metabolism-related genes in DEGs, displaying significant differences between WT and cobll1a mutant. (C) RT-qPCR analysis of the transcriptional expression level of RA metabolism-related genes at 52 hpf cobll1a^−/− compared with WT. (D, F) The expression of aldh1a2 was decreased in cobll1a^−/−embryos, observed in eye and somatic cells at 24 hpf, in liver and intestinal tissues at four dpf. (E) At 4 dpf, the expression of rdh10 was decreased in cobll1a^−/− embryos. (G) At 4 dpf, the expression of cyp26a1 was increased in cobll1a^−/− embryos. (H) At 4dpf, the expression of rbp4 was decreased in cobll1a^−/− embryos.

Expression Data

Genes:	aldh1a2 cyp26a1 raraa rarab rarga rargb rbp4 rdh10b stra6
Fish:	TU cobll1a^hn17/hn17 (TU)
Anatomical Terms:	eye intestine liver trunk whole organism
Stage Range:	Prim-5 to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cobll1a^hn17/hn17 (TU)
Observed In:	eye intestine liver retinoic acid metabolic process trunk whole organism
Stage Range:	Prim-5 to Day 4

Phenotype Detail

Acknowledgments

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