Gene
raraa
- ID
- ZDB-GENE-980526-284
- Name
- retinoic acid receptor, alpha a
- Symbol
- raraa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Exhibits nuclear receptor activity. Involved in hindbrain morphogenesis; liver development; and response to retinoic acid. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia; lung cancer (multiple); and syndromic microphthalmia. Is expressed in several structures, including endoderm; gonad; mesoderm; nervous system; and neural keel. Orthologous to several human genes including RARA (retinoic acid receptor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- s74155 (28 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Garnaas et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute promyelocytic leukemia | Alliance | Leukemia, acute promyelocytic | 612376 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR047158 | Retinoic acid receptor, ligand-binding domain |
| Domain | IPR047159 | Retinoic acid receptor, DNA-binding domain |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003078 | Retinoic acid receptor |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Retinoic acid receptor | Retinoic acid receptor, DNA-binding domain | Retinoic acid receptor, ligand-binding domain | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90271
|
444 | ||||||||
|
UniProtKB:T2DKU4
|
447 |
Interactions and Pathways
Plasmids
No data available