FIGURE

Fig. 6

ID

ZDB-FIG-240329-52

Publication

Endo et al., 2023 - Two zebrafish cacna1s loss-of-function variants provide models of mild and severe CACNA1S-related myopathy

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Fig. 6

Characterization of adult cacna1s mutants. (A) Representative appearance of 7 months-old fish. cacna1s-aKO and cacna1s-aKO-bHet fish were smaller than WT, with cacna1s-aKO-bHet showing protruding jaw (arrow). Scale bar = 5 mm. (B) Schematic showing standard length, total length, and body depth measurements. (C) Standard length, total length, and body depth were measured and plotted; WT siblings (n = 15), dHet (n = 10, green), aKO (n = 11) and aKO-bHet (n = 13). All values are mean ± SEM (see Supplementary Table S1). Differences were analyzed by Tukey’s multiple comparisons test and considered to be statistically significant at P < 0.05 (*), P < 0.01 (**) P < 0.001 (***) or P < 0.0001(****).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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