Figure 8.
- ID
- ZDB-FIG-240111-41
- Publication
- Heins-Marroquin et al., 2024 - CLN3 deficiency leads to neurological and metabolic perturbations during early development
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Proposed changes induced by CLN3 deficiency along the endolysosomal pathway In healthy cells, the number of intraluminal vesicles (ILVs) increases in the early endosomes to form multilamellar bodies in the late endosomes. The latter fuse with lysosomes forming a hybrid transient endolysosome to finally form secondary lysosomes. BMP is enriched in ILVs, and its levels increase during endosome maturation, contributing to ILV formation, ceramide degradation, and cholesterol efflux ( |