FIGURE

Figure S8.

ID

ZDB-FIG-240111-35

Publication

Heins-Marroquin et al., 2024 - CLN3 deficiency leads to neurological and metabolic perturbations during early development

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Figure S8.

Indications for impaired proteolytic activity in MUT1 larvae.

(A) Heatmap diagrams from untargeted metabolomics experiments 1 and 2 generated from significantly different oligopeptides containing one prolyl residue. (B) CtsD activity assay in WT and MUT1 extracts showing a mild, not statistically significant, decrease in activity in the MUT1 line. (B, C) Western blot analysis of CtsD protein levels in the zebrafish extracts used for the activity assays in panel (B). (D) Representative electron micrographs of intestine and liver cells of 60-nm sagittal sections of WT and MUT1 larvae at 6 dpf. No fingerprint-like structures were observed in the MUT1 samples. Scale bars represent 3 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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