FIGURE

Fig. EV6

ID

ZDB-FIG-231121-73

Publication

Lescouzères et al., 2023 - A multilevel screening pipeline in zebrafish identifies therapeutic drugs for GAN

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Fig. EV6

Beneficial effect of the Hits upon treatment at symptomatic stage A. Phenotype of gan MO-injected embryos at 48 hpf, with deficits in touch-responsiveness and impairment of axons and neuromuscular junctions (znp1: green; αBTX: α-bungarotoxin: red). Scale bar represents a length of 100 μm. B–E. Restoration of motility of 5-day-old gan larvae, when treated from 48 hpf with Aceclidine Hydrochloride (Acecl.) (B), Oxymetazoline Hydrochloride (Oxymet.) (C), Trichlormethiazide (Trichlor.) (D) and Phentolamine Hydrochloride (Phento.) (E). Hits were applied from 5 to 30 μM concentrations, with daily bath changes; data are not provided for the higher doses (20 and 30 μM) due to toxicity. Results show the distance traveled during 1 h by gan MO-injected larvae, treated with either DMSO or Hits at 5 and 10 μM. In the absence of normality of distribution of the data, a nonparametric Kruskal–Wallis test is applied; means ± SEM are represented. **P ≤ 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.