FIGURE

Fig. 4.

ID

ZDB-FIG-231002-108

Publication

Leid et al., 2023 - Deletion of taf1 and taf5 in zebrafish capitulate cardiac and craniofacial abnormalities associated with TAFopathies through perturbations in metabolism

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Fig. 4.

cora^stl325 encodes a nonsense mutation in taf5. (A) Workflow for mapping cora^stl325 using whole genome next generation sequencing. (B) Manhattan plot displaying homozygosity ratio for the AB* background (y-axis) as a function of chromosome location (x-axis). A value of 2.0 indicates 100% homozygosity for the AB* background. Chr. 1: chromosome 1. (C) Fine chromosomal mapping identified a 24 cM region (red box) that was linked with the cora^stl325 phenotype (top). Genotyping to identify the point mutation leading to a nonsense mutation in taf5. The nonsense mutation was linked to the cora^stl325 phenotype (bottom). (D) Graphical representation of the taf5 genomic locus and TAF5 protein including major functional domains. Red box indicates the mutated base and resulting nonsense mutation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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