FIGURE

Fig. 2.

ID

ZDB-FIG-231002-106

Publication

Leid et al., 2023 - Deletion of taf1 and taf5 in zebrafish capitulate cardiac and craniofacial abnormalities associated with TAFopathies through perturbations in metabolism

Other Figures

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Fig. 2.

cora^stl325 hearts display hypoplasia and reduced proliferation. (A) Fluorescent microscopy images of 96 hpf embryos (left, cmlc2::GFP; n=8) and H&E staining (right; n=4). (B) Fluorescent microscopy images of 96 hpf embryos stained with the SF46 (orange) and MF20 (green) showing normal atrioventricular patterning (left). Electron microscopy showing intact sarcomeres in control and cora^stl325 cardiomyocytes (right; n=4). (C) Brightfield and fluorescence microscopy time-course of cmlc2::GFP expression between 48 and 120 hpf (Control (n=12) and cora^stl325 (n=8). (D) Quantification of atrial and ventricular cross-sectional areas obtained from C [Control (n=12) and cora^stl325 (n=8)]. (E) BrdU immunostaining (red) of 96 hpf embryos embedded in paraffin [Control (n=6) and cora^stl325 (n=12)].

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	taf5^{stl325/stl325} taf5^{stl325/stl325}; twu34Tg
Observed In:	atrium cardiac muscle cell sarcomere cardiac ventricle myocardium cell population proliferation
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

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