FIGURE

Figure 2

ID

ZDB-FIG-230630-25

Publication

Stemerdink et al., 2023 - Generation and Characterization of a Zebrafish Model for ADGRV1-Associated Retinal Dysfunction Using CRISPR/Cas9 Genome Editing Technology

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Figure 2

Localization of Adgrv1 in retinal cryosections of wild-type and adgrv1^rmc22 zebrafish. Retinal cryosections of wild-type and adgrv1^rmc22 zebrafish larvae (5 dpf) labeled with antibodies directed against Adgrv1 (red) and centrin (green) (as shown by the schematic representation on the right). Nuclei are counterstained with DAPI (blue). In wild-type larvae, Adgrv1 was detected adjacent to the connecting cilium marker centrin, whereas in adgrv1^rmc22 zebrafish no Adgrv1 signal could be detected at this location. Scale bar: 10 μm. OS: outer segment; CC: connecting cilium; IS: inner segment; ONL: outer nuclear layer.

Expression Data

Gene:	adgrv1
Antibodies:	Ab1-cetn Ab2-adgrv1
Fish:	AB adgrv1^rmc22/rmc22 (AB)
Anatomical Term:	retinal outer nuclear layer photoreceptor connecting cilium
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	adgrv1^rmc22/rmc22 (AB)
Observed In:	retinal outer nuclear layer photoreceptor connecting cilium
Stage:	Day 5

Phenotype Detail

Acknowledgments

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