FIGURE

Figure 5

ID

ZDB-FIG-230630-29

Publication

Stemerdink et al., 2023 - Generation and Characterization of a Zebrafish Model for ADGRV1-Associated Retinal Dysfunction Using CRISPR/Cas9 Genome Editing Technology

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Figure 5

Electroretinogram recordings reveal impaired retinal function in adgrv1^rmc22 juveniles. (A): Representative ERG traces of an adgrv1^rmc22 and a wild-type zebrafish. (B): The adgrv1^rmc22 zebrafish show a significant decrease in maximum B-wave amplitude when compared to wild-type zebrafish (* p < 0.01, two-tailed unpaired Student’s t-test). ERG traces were recorded on the eyes of juvenile zebrafish (n = 35 adgrv1^rmc22 mutants and n = 31 wild-types, 6–8 weeks post fertilization). The average wild-type B-wave amplitude was normalized to 1. Mean B-wave amplitude ± SD is plotted in the bar graph.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	adgrv1^rmc22/rmc22 (AB)
Observed In:	visual perception
Stage Range:	Days 30-44 to Days 45-89

Phenotype Detail

Acknowledgments

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