Gene
adgrv1
- ID
- ZDB-GENE-040624-6
- Name
- adhesion G protein-coupled receptor V1
- Symbol
- adgrv1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and adenylate cyclase inhibitor activity. Acts upstream of or within eye photoreceptor cell development. Predicted to be located in photoreceptor inner segment and stereocilium membrane. Predicted to be active in cytoplasm and stereocilium. Is expressed in integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Usher syndrome type 2C and familial febrile seizures 4. Orthologous to human ADGRV1 (adhesion G protein-coupled receptor V1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139473 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Stemerdink et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial febrile seizures 4 | Alliance | ?Febrile seizures, familial, 4 | 604352 |
| Usher syndrome type 2C | Alliance | Usher syndrome, type 2C | 605472 |
| Usher syndrome type 2C | Alliance | Usher syndrome, type 2C, GPR98/PDZD7 digenic | 605472 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| retinitis pigmentosa | adgrv1rmc22/rmc22 (AB) | standard conditions | Stemerdink et al., 2023 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000203 | GPS motif |
| Domain | IPR003609 | PAN/Apple domain |
| Domain | IPR003644 | Na-Ca exchanger/integrin-beta4 |
| Domain | IPR006558 | LamG-like jellyroll fold |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR026919 | Adhesion G-protein coupled receptor V1 |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR038081 | CalX-like domain superfamily |
| Homologous_superfamily | IPR046338 | GAIN domain superfamily |
| Repeat | IPR009039 | EAR |
Domain Details Per Protein
| Protein | Length | Adhesion G-protein coupled receptor V1 | CalX-like domain superfamily | Concanavalin A-like lectin/glucanase domain superfamily | EAR | GAIN domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPS motif | LamG-like jellyroll fold | Na-Ca exchanger/integrin-beta4 | PAN/Apple domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BD08
|
6201 | |||||||||||
|
UniProtKB:Q6JAN0
|
6199 | |||||||||||
|
UniProtKB:F1QEZ1
|
6198 | |||||||||||
|
UniProtKB:A0A8M3ASR0
|
6208 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adgrv1-201
(1)
|
Ensembl | 19,174 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-adgrv1 | polyclonal | Rabbit |
|
3 | |||
| Ab2-adgrv1 | polyclonal | IgG | Rabbit |
|
Boster Biological
|
2 |
Plasmids
No data available