Gene
adgrv1
- ID
- ZDB-GENE-040624-6
- Name
- adhesion G protein-coupled receptor V1
- Symbol
- adgrv1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and adenylate cyclase inhibitor activity. Involved in eye photoreceptor cell development. Predicted to localize to integral component of membrane; photoreceptor inner segment; and stereocilium membrane. Human ortholog(s) of this gene implicated in Usher syndrome type 2C and familial febrile seizures 4. Is expressed in integument; nervous system; and pleuroperitoneal region. Orthologous to human ADGRV1 (adhesion G protein-coupled receptor V1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139473 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Stemerdink et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial febrile seizures 4 | Alliance | ?Febrile seizures, familial, 4 | 604352 |
| Usher syndrome type 2C | Alliance | Usher syndrome, type 2C | 605472 |
| Usher syndrome type 2C | Alliance | Usher syndrome, type 2C, GPR98/PDZD7 digenic | 605472 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| retinitis pigmentosa | adgrv1rmc22/rmc22 (AB) | standard conditions | Stemerdink et al., 2023 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000203 | GPS motif |
| Domain | IPR003609 | PAN/Apple domain |
| Domain | IPR003644 | Na-Ca exchanger/integrin-beta4 |
| Domain | IPR006558 | LamG-like jellyroll fold |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR026919 | Adhesion G-protein coupled receptor V1 |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR038081 | CalX-like domain superfamily |
| Homologous_superfamily | IPR046338 | GAIN domain superfamily |
| Repeat | IPR009039 | EAR |
Domain Details Per Protein
| Protein | Length | Adhesion G-protein coupled receptor V1 | CalX-like domain superfamily | Concanavalin A-like lectin/glucanase domain superfamily | EAR | GAIN domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPS motif | LamG-like jellyroll fold | Na-Ca exchanger/integrin-beta4 | PAN/Apple domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BD08
|
6201 | |||||||||||
|
UniProtKB:Q6JAN0
|
6199 | |||||||||||
|
UniProtKB:F1QEZ1
|
6198 | |||||||||||
|
UniProtKB:A0A8M3ASR0
|
6208 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adgrv1-201
(1)
|
Ensembl | 19,174 nt |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-adgrv1 | polyclonal | Rabbit |
|
3 | |||
| Ab2-adgrv1 | polyclonal | IgG | Rabbit |
|
Boster Biological
|
2 |
Plasmids
No data available