FIGURE

Fig. 2

ID

ZDB-FIG-230510-3

Publication

Okeke et al., 2022 - Control of cranial ectomesenchyme fate by Nr2f nuclear receptors

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Fig. 2

Behavior of non-ectomesenchyme and early NC genes in nr2f2^el/el;nr2f5^el/el mutants. (A) In situ hybridizations analysis showing that markers of alternate lineages are not overtly upregulated at 20 hpf. (B) In situ hybridizations for early NC genes in control and double mutants at 20 hpf. Arrowheads indicate elevated sox10 expression. In A,B, top right numbers are the average TPM values in the RNAseq data, with the log2-transformed fold-change DESeq2 values underneath. (C) Immunostaining showing ectopic Sox10 protein in the arches (outlined) at 25 hpf. sox10:kikGR marks NC-derived cells. Scale bars: 100 µm.

Expression Data

Genes:	foxd3 gch2 msx1a nr4a2b sox9b sox10 tfap2a zic2a
Antibody:	Ab3-sox10
Fish:	nr2f2^el506/el506; nr2f5^el611/el611 nr2f2^el506/el506; nr2f5^el611/el611; el2Tg/el2Tg
Anatomical Terms:	cranial neural crest cell neuron pigment cell
Stage Range:	20-25 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nr2f2^el506/el506; nr2f5^el611/el611
Observed In:	cranial neural crest cell
Stage Range:	20-25 somites to Prim-5

Phenotype Detail

Acknowledgments

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