Gene
nr4a2b
- ID
- ZDB-GENE-040718-103
- Name
- nuclear receptor subfamily 4, group A, member 2b
- Symbol
- nr4a2b Nomenclature History
- Previous Names
-
- nr4a2
- ngf1b
- NURR1 (1)
- zgc:92696
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear glucocorticoid receptor binding activity. Acts upstream of or within dopaminergic neuron differentiation; forebrain neuron development; and neutrophil homeostasis. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including atrioventricular canal endocardium; basal plate midbrain region; blood; nervous system; and neuroblasts. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92696 (43 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder with language impairment and early-onset DOPA-responsive dystonia-parkinsonism | 619911 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003070 | Nuclear receptor subfamily 4 group A member 1-3 |
| Family | IPR003073 | Nuclear receptor subfamily 4 group A member 2 |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Nuclear receptor subfamily 4 group A member 1-3 | Nuclear receptor subfamily 4 group A member 2 | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DH08 | InterPro | 586 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nr4a2b-201
(1)
|
Ensembl | 2,863 nt | ||
| mRNA |
nr4a2b-202
(1)
|
Ensembl | 2,791 nt |
Interactions and Pathways
Plasmids
No data available