FIGURE

Fig. 6

ID

ZDB-FIG-230115-63

Publication

Brandt et al., 2021 - Ablation of mpeg+ Macrophages Exacerbates mfrp-Related Hyperopia

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Fig. 6

Proliferative effects of mfrp deletion and macrophage ablation. (A–H) Representative images of central retina sections from mfrp⁺^/^–; mpeg1:NTR-eYFP⁺ and mfrp^–^/^–; mpeg1:NTR-eYFP⁺ MTZ treated and untreated fish. (A–H) Grayscale DAPI images at low magnification (A, C, E, G) and high magnification (B, D, F, H). (A'–H') Grayscale PCNA images at low magnification (A', C', E', G') and high magnification (B', D', F', H'). (A''–H'') Colorized merged images with DAPI in blue and PCNA in green; images are at low magnification (A'', C'', E'', G'') and high magnification (B'', D'', F'', H''). (I–J) Quantification of the percentage of PCNA⁺ nuclei in the inner (I) and outer (J) nuclear layer. Error bars represent standard deviations. Two-way ANOVA was used for statistical analysis for (I) and (J). P values are shown from Tukey's multiple comparisons for post hoc analysis. For mfrp⁺^/^– untreated, n = 5; for mfrp⁺^/^– MTZ treated, n = 6; for mfrp^–^/^– untreated, n = 5; for mfrp^–^/^– MTZ treated, n = 5.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mfrp^mw78/+; w202Tg/w202Tg mfrp^mw78/mw78; w202Tg/w202Tg
Condition:	chemical treatment by environment: metronidazole
Observed In:	retinal inner nuclear layer cell division retinal outer nuclear layer cell division
Stage:	Days 45-89

Phenotype Detail

Acknowledgments

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