FIGURE

Figure 2.

ID

ZDB-FIG-221211-83

Publication

Ikle et al., 2022 - Genome-edited zebrafish model of ABCC8 loss-of-function disease

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Figure 2.

SUR1 LOF [499X] abolishes K_ATP channel activity (a) Representative K_ATP channel activity in inside-out patch clamp recordings from inside-out patch clamp recordings of WT (above) and homozygous SUR1[499X] (SUR1^−/−) mutant β-cells (below) in the presence of ATP (μM), or addition of diazoxide (mM), as indicated. Voltage was clamped at −50 mV. (b) KATP channel density in WT and SUR1-/- patches (n = 17,10).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	abcc8^{sa15863/sa15863}; sc1Tg (AB)
Observed In:	pancreatic B cell ATP-activated inward rectifier potassium channel activity
Stage:	Adult

Phenotype Detail

Acknowledgments

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