FIGURE

Figure 3.

ID

ZDB-FIG-221211-85

Publication

Ikle et al., 2022 - Genome-edited zebrafish model of ABCC8 loss-of-function disease

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Figure 3.

SUR1^−/− islets exhibit elevated basal [Ca2+] and reduced responsivity to glucose (a) Representative recordings of intracellular calcium in the presence of 2 mM glucose (2 G) and following switch to 20 mM glucose (20 G) and then 30 mM KCl (30 K), for WT (above, n = 6) and SUR1^−/− (below, n = 12). Fluorescence is normalized to maximum fluorescence in 30 K (f = 1), and minimum fluorescence (f = 0) anywhere within the record. Values for each islet are also shown. (b) Average calcium in each condition for WT (N = 8) and SUR1^−/− (n = 14). Data in B are analyzed by 1-way ANOVA followed by multiple unpaired t-tests. (*) p < .05, (**) p < .01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	abcc8^{sa15863/sa15863}; stl441Tg (AB)
Observed In:	pancreatic B cell calcium cation pancreatic B cell cellular response to glucose stimulus
Stage:	Adult

Phenotype Detail

Acknowledgments

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