FIGURE

Figure 1.

ID

ZDB-FIG-221211-70

Publication

Ikle et al., 2022 - Genome-edited zebrafish model of ABCC8 loss-of-function disease

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Figure 1.

Genome-modified zebrafish model of SUR1 LOF (a) Schematic of SUR1 protein structure showing functional domains and indicating location of premature stop mutation (K499X) within TMD1. (b) Body weight in WT (n = 11), heterozygous SUR1 mutants (n = 12) and SUR1 knockout (n = 12) fish at age 8 weeks. Density of β-cell within individual islets is not different between WT (n = 5) and SUR1 mutant (n = 15). (c) Fasting blood glucose over time shows no significant difference between homozygous mutants and controls (n = 11–16 per timepoint). (d) Blood glucose versus time in response to glucose load in SUR1^−/−, WT and SUR1+/- fish (n = 8–16 per timepoint).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	abcc8^{sa15863/sa15863} (AB) abcc8^sa15863/+ (AB)
Conditions:	chemical treatment by injection: glucose fasting
Observed In:	blood glucose endocrine pancreas pancreatic B cell whole organism
Stage Range:	Days 21-29 to Adult

Phenotype Detail

Acknowledgments

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