FIGURE

Fig. 2

ID

ZDB-FIG-221207-14

Publication

Jia et al., 2022 - Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Photoreceptor degeneration and defective protein transport in tulp1-dKO zebrafish.

A Sections were stained with rod-specific marker Rhodopsin, green cone-specific marker Opn1mw1, red cone-specific marker Opn1lw1, blue cone-specific marker Opn1sw2, and UV cone-specific marker Opn1sw1 at 3 dpf, 5 dpf, 20 dpf, and 4 mpf. ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer. Scale bar: 15 µm. B TEM of the photoreceptors of wt and tulp1-dKO zebrafish at 5 dpf. The higher-magnification images within the rectangles (in a and b) are shown on the right (a’ and b’). Scale bar: 2 µm. C Relative mRNA expression of gnat1 and gnat2 in wt and tulp1-dKO zebrafish at 4 dpf. Mean ± SD (n = 3). ****P < 0.0001. D Gnat1 and Gnat2 were detected by western blot.

Expression Data

Genes:	gnat1 gnat2
Antibodies:	Ab1-gnat1 Ab2-gnat2 Ab2-opn1sw2 Ab5-rho
Fish:	WT tulp1a^hzu18/hzu18; tulp1b^hzu19/hzu19
Anatomical Terms:	eye head long single cone cell retinal rod cell
Stage Range:	Protruding-mouth to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tulp1a^hzu18/hzu18; tulp1b^hzu19/hzu19
Observed In:	eye head long single cone cell retina photoreceptor disc membrane retinal photoreceptor layer retinal rod cell
Stage Range:	Protruding-mouth to Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Death Dis.