Gene

gnat2

ID

ZDB-GENE-011128-10

Name

guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2

Symbol

gnat2 Nomenclature History

Previous Names

GNAT3 (1)
nof
Galpha t2 (1)
no optokinetic response f
T alpha C (1)
Tc alpha (1)
transducin alpha (cone) (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in detection of light stimulus involved in visual perception. Predicted to localize to heterotrimeric G-protein complex. Used to study achromatopsia and cone-rod dystrophy. Human ortholog(s) of this gene implicated in achromatopsia 4 and color blindness. Is expressed in pineal complex and visual system. Orthologous to several human genes including GNAT2 (G protein subunit alpha transducin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

51 figures from 35 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Phenotype Annotation (1994-2006)
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gnat2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
achromatopsia 4	Alliance	Achromatopsia 4	613856

Associated With gnat2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
cone-rod dystrophy	gnat2^w21/w21 (AB)	standard conditions	Brockerhoff et al., 2003
achromatopsia	gnat2^w21/w21 (AB)	standard conditions	Kennedy et al., 2007

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
Family	IPR001408	G-protein alpha subunit, group I
Homologous_superfamily	IPR011025	G protein alpha subunit, helical insertion
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	G-protein alpha subunit, group I	G protein alpha subunit, helical insertion	Guanine nucleotide binding protein (G-protein), alpha subunit	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q90WX5 InterPro	354

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gnat2-201 (1) Ensembl	Ensembl	2,170 nt	Select Tool
mRNA	gnat2-202 (1) Ensembl	Ensembl	760 nt	Select Tool
ncRNA	gnat2-003 (1) Ensembl	Ensembl	2,170 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab3-gnat2	polyclonal	gnat2		Rabbit	IHC		4
Ab1-gnat2	polyclonal	gnat2		Rabbit	IHC WB		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations