Gene

gnat2

ID

ZDB-GENE-011128-10

Name

guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2

Symbol

gnat2 Nomenclature History

Previous Names

GNAT3 (1)
nof
Galpha t2 (1)
no optokinetic response f
T alpha C (1)
Tc alpha (1)
transducin alpha (cone) (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Acts upstream of or within detection of light stimulus involved in visual perception. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in photoreceptor inner segment and photoreceptor outer segment. Is expressed in pineal complex and visual system. Used to study achromatopsia and cone-rod dystrophy. Human ortholog(s) of this gene implicated in achromatopsia 4 and color blindness. Orthologous to human GNAT2 (G protein subunit alpha transducin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

51 figures from 35 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Phenotype Annotation (1994-2006)
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gnat2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
achromatopsia 4	Alliance	Achromatopsia 4	613856

Associated With gnat2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
cone-rod dystrophy	gnat2^w21/w21 (AB)	standard conditions	Brockerhoff et al., 2003
achromatopsia	gnat2^w21/w21 (AB)	standard conditions	Kennedy et al., 2007

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
Family	IPR001408	G-protein alpha subunit, group I
Homologous_superfamily	IPR011025	G protein alpha subunit, helical insertion
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	G-protein alpha subunit, group I	G protein alpha subunit, helical insertion	Guanine nucleotide binding protein (G-protein), alpha subunit	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q90WX5 InterPro	354

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gnat2-201 (1) Ensembl	Ensembl	2,170 nt	Select Tool ZFIN BLAST
mRNA	gnat2-202 (1) Ensembl	Ensembl	760 nt	Select Tool ZFIN BLAST
mRNA	gnat2-203 (1) Ensembl	Ensembl	630 nt	Select Tool ZFIN BLAST
ncRNA	gnat2-003 (1) Ensembl	Ensembl	2,170 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab3-gnat2	polyclonal	gnat2		Rabbit	IHC		4
Ab1-gnat2	polyclonal	gnat2		Rabbit	IHC WB		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations