Gene
gnat1
- ID
- ZDB-GENE-011128-11
- Name
- guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
- Symbol
- gnat1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and response to light stimulus. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in pineal complex and visual system. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1G; congenital stationary night blindness autosomal dominant 3; and night blindness. Orthologous to human GNAT1 (G protein subunit alpha transducin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 43 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73094 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital stationary night blindness 1G | Alliance | Night blindness, congenital stationary, type 1G | 616389 |
| congenital stationary night blindness autosomal dominant 3 | Alliance | Night blindness, congenital stationary, autosomal dominant 3 | 610444 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001019 | Guanine nucleotide binding protein (G-protein), alpha subunit |
| Family | IPR001408 | G-protein alpha subunit, group I |
| Homologous_superfamily | IPR011025 | G protein alpha subunit, helical insertion |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | G-protein alpha subunit, group I | G protein alpha subunit, helical insertion | Guanine nucleotide binding protein (G-protein), alpha subunit | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|
|
UniProtKB:Q90WX6
|
350 |
Interactions and Pathways
No data available
Plasmids
No data available