FIGURE

Figure 5

ID

ZDB-FIG-220920-31

Publication

Meyer-Miner et al., 2022 - Resolving primary pathomechanisms driving idiopathic-like spinal curvature using a new katnb1 scoliosis model

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Figure 5

katnb1 mutants exhibit severe fChP and rChp cilia defects at 30 dpf

(A–D) Representative maximum intensity Z-stack projections of confocal micrographs, acquired through dorsally oriented whole mount brains that were dissected from 30 dpf katnb1^mh102/+ control (A–B; N = 11, n = 70) and katnb1^mh102/mh102 mutant (C-D; N = 11, n = 88) fish, and immunostained for polyglutamylated tubulin. Forebrain ChP (A, C) and rhombencephalic ChP (B, D) are shown. Squares represent higher magnification images of fChP (A′, C′) and rChP (B′, D′). Scale bars, 50 μm (A & B) and 20 μm (A' & B′).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	katnb1^mh102/mh102
Observed In:	choroid plexus fourth ventricle choroid plexus third ventricle multi-ciliated epithelial cell
Stage:	Days 30-44

Phenotype Detail

Acknowledgments

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