FIGURE

Figure 3

ID

ZDB-FIG-220920-29

Publication

Meyer-Miner et al., 2022 - Resolving primary pathomechanisms driving idiopathic-like spinal curvature using a new katnb1 scoliosis model

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Figure 3

Re-introduction of Katnb1 in foxj1a-positive cell lineages suppresses scoliosis

(A) Schematic of Tg(foxj1a::katnb1) construct.

(B–E) SEM images of the rhombencephalic ventricle of 3 month old katnb1^mh102/mh102 (B & C; N = 4, n = 11) and Tg(foxj1a::katnb1); katnb1^mh102/mh102 (D & E; N = 4, n = 10) fish. (B, D) Scale bar, 20 μm. Square indicates higher magnification location. (C, E) Scale bar, 5 μm.

(F–I) Representative microCT projections of 3-month-old katnb1^mh102/mh102 (F & G; N = 17, n = 68) and Tg(foxj1a::katnb1); katnb1^mh102/mh102 (H & I; N = 8, n = 73) mutant zebrafish in sagittal (F & H) and coronal (G & I) planes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	katnb1^mh102/mh102 katnb1^mh102/mh102; hsc193Tg
Observed In:	fourth ventricle multi-ciliated epithelial cell vertebral column
Stage:	Adult

Phenotype Detail

Acknowledgments

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