FIGURE

Fig. 3

ID

ZDB-FIG-220908-25

Publication

Ma et al., 2022 - Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress

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Fig. 3

Digestive organ bud initiation is unaffected in ercc2/xpd mutants

(A) Whole-mount in situ hybridization (WISH) of marker genes for digestive organ budding in ercc2/xpd mutants and siblings at 2 dpf. Dorsal view, anterior to the top. l, liver; p, pancreas; i, intestine. After individual imaging, embryos were subjected to individual genotyping. Scale bars, 100 μm.

(B) WISH of marker genes for early development of digestive organs in ercc2/xpd mutants and siblings at 3 and 4 dpf. Upper: dorsal view, anterior to the top; lower: lateral view, anterior to the left. After individual imaging, embryos were subjected to individual genotyping. Scale bars, 100 μm.

(C) Tg(fabp10a:dsRed; ela3l:GFP) revealed early development of digestive organs in ercc2/xpd mutants and siblings at 4 dpf. After individual imaging, embryos were subjected to individual genotyping. Scale bars, 100 μm.

Expression Data

Genes:	DsRed EGFP ela3l fabp2 foxa3 gata6 hhex pdx1 prss1
Fish:	AB ercc2^{whu312/whu312} gz15Tg ercc2^whu312/+; gz15Tg ercc2^{whu312/whu312}; gz15Tg
Anatomical Terms:	digestive system exocrine pancreas intestine liver pancreas
Stage Range:	Long-pec to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ercc2^{whu312/whu312} ercc2^{whu312/whu312}; gz15Tg
Observed In:	intestine liver pancreas
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

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