FIGURE

Figure 7

ID

ZDB-FIG-220827-20

Publication

Crouzier et al., 2022 - Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines

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Figure 7

Relative gene expression levels of ER stress factors in zebrafish larvae at 5 dpf exposed to tunicamycin during 24 h. Expression analysis of the selected genes using cDNA prepared from wfs1a^C825X (A) and wfs1b^W493X (B) zebrafish larvae. The relative expression levels of mRNA are represented as the fold change from the control vehicle group. Data are expressed in mean ± SEM, n = 5 in each group. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 versus DMSO condition, °P < 0.05, °°°P < 0.001 versus WT condition; two-way ANOVA, unpaired t-test.

Expression Data

Genes:	atf4a atf4b atf6 ddit3 eif2s1b hsp90b1 hspa5 sigmar1 xbp1
Fish:	AB wfs1a^{sa11465/sa11465} (AB) wfs1b^{sa16422/sa16422} (AB)
Condition:	chemical treatment by environment: tunicamycin
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB wfs1a^{sa11465/sa11465} (AB) wfs1b^{sa16422/sa16422} (AB)
Condition:	chemical treatment by environment: tunicamycin
Observed In:	whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

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