Gene
ddit3
- ID
- ZDB-GENE-070410-90
- Name
- DNA-damage-inducible transcript 3
- Symbol
- ddit3 Nomenclature History
- Previous Names
-
- CHOP (1)
- zgc:162630
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; regulation of lipid biosynthetic process; and response to hypoxia. Predicted to localize to CHOP-ATF3 complex; RNA polymerase II transcription factor complex; and cytoplasm. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Is expressed in brain; caudal fin; digestive system; and head. Orthologous to human DDIT3 (DNA damage inducible transcript 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 62 figures from 53 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Her et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Basic-leucine zipper domain | DNA damage-inducible transcript 3 |
|---|---|---|---|
|
UniProtKB:F1Q964
|
242 | ||
|
UniProtKB:A3KNX2
|
205 |
Interactions and Pathways
No data available
Plasmids
No data available