FIGURE
Fig. 6
- ID
- ZDB-FIG-220628-104
- Publication
- Morrison et al., 2022 - Single-cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver
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Fig. 6
Identifying key alterations in Mpi-depleted cholangiocytes. (A) Bar graph showing Mpi enzymatic activity in WT and mpi+/mss14 adult zebrafish livers. (B) Immunofluorescent staining for 2f11 and Col1a1 on WT and mpi+/mss14 adult zebrafish liver cryosections imaged at magnification ×63. (C) Dot plot of receptor–ligand interaction scores determined by CellPhoneDB analysis of scRNA-seq gene expression in WT and mpi+/mss7 zebrafish liver cells. Dot color indicates log2(mean expression score) with values closest to zero indicating the highest expression score. −Log10(p value) is represented by dot size, with increasing dot size indicating increasing significance. (D) Immunofluorescent staining for 2f11 and Nrp1 on WT and mpi+/mss14 adult zebrafish liver cryosections imaged at magnification ×63. White arrows indicate representative bile ducts for each sample. (E) Violin plot for Nrp1 expression in Sox9+ cholangiocytes from scRNA-seq data on livers from control, BDL, and CCl4-treated mice. **p < 0.01, ***p < 0.001
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Expression Data
| Antibodies: | |
|---|---|
| Fish: | |
| Anatomical Terms: | |
| Stage: | Adult |
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
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| Observed In: | |
| Stage: | Adult |
Phenotype Detail
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