FIGURE
Fig. 5
- ID
- ZDB-FIG-220628-103
- Publication
- Morrison et al., 2022 - Single-cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver
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Fig. 5
Activation phenotypes are conserved across human and zebrafish HSCs. (A) Bar graph showing MPI enzymatic activity in WT and MPI MT LX-2 cells. (B) Western blot for MPI and COL1A in WT and MPI MT LX-2 cells. (C) Bar graph showing MPI enzymatic activity in control and siMPI TWNT-4s. (D,E) IPA conducted on DGE from the following three data sets: mpi+/mss7 zebrafish single-cell HSCs (zHSCs), MPI mutant LX-2 HSCs, and siMPI TWNT-4 HSCs. Heatmaps display (D) −log10(p values) for canonical pathway activity alteration and (E) z score of activation/inhibition of upstream regulators. *p < 0.05, **p < 0.01. ILK, integrin-linked kinase; LXR, liver X receptor; RXR, retinoid X receptor; STAT3, signal transducer and activator of transcription 3
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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