FIGURE

Fig. 1

ID

ZDB-FIG-220623-19

Publication

Wilcock et al., 2022 - Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached

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Fig. 1

Figure 1. DGAT1 amplification and up-regulation is associated with poor prognosis in melanoma (A) Patient survival from TCGA melanoma cohort (25% top versus 75% bottom by mRNA abundance, y axis) versus fold change in mRNA expression of lipid metabolism genes in zebrafish tumors (x axis). (B) Kaplan-Meier survival plot comparing melanoma patients based on expression of DGAT1 or DGAT2 (top 25% versus bottom 75%, TCGA dataset). (C) DGAT1 and DGAT2 relative gene expression in skin, nevi, and melanoma tumors from indicated studies. Mean ± SD, n > 3. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001. (D) Protein expression of DGAT1 and vinculin (loading control). NHM, normal human melanocytes. (E) Genetic alterations in the TCGA firehose legacy melanoma dataset (counting only samples with CNV data) obtained from cBioPortal. (F) Schematic depicting human chromosome 8, the amplified arm (red), and known/putative melanoma oncogenes within this region. (G) G-score of amplified regions of zebrafish chromosomes found in BRAFV600E-positive; tp53 mutant tumors indicating the position of presumed melanoma oncogene homologs. (H) Kaplan-Meier progression free-survival plot comparing patients across multiple cancer types based on DGAT1 amplification.

Expression Data

Genes:	dgat1a gdf6a
Fish:	tp53^zdf1/zdf1; czt13Tg/czt13Tg
Condition:	in vitro culture: melanocyte
Anatomical Term:	integument melanoma
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/zdf1; czt13Tg/czt13Tg
Condition:	in vitro culture: melanocyte
Observed In:	integument melanoma
Stage:	Adult

Phenotype Detail

Acknowledgments

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